Transform Evolution into Actionable Genomic Insight

CodeXome converts 80 million years of primate evolution into a searchable, computable evidence layer for variant interpretation — no bioinformatics background required.

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Used by research teams, clinicians, and bioinformatics groups advancing variant interpretation globally

Evolution-powered interpretation, step by step

Follow the flow of data through CodeXome — from raw evolutionary alignment to gene-level interpretation tools.

Deep Time Ancestry

A unified evolutionary record

CodeXome aggregates primate exomes into a single deep-time alignment, mapping millions of natural amino-acid substitutions to human GRCh38 coordinates. This ancestral record becomes the foundation for all downstream interpretation.

Phylogenetic tree and multiple sequence alignment of primate species showing amino acid variations at positions 1147 to 1186.

From raw alignment to ready-to-use insights

CodeXome converts the evolutionary alignment into computable metrics — constraint scoring, tolerated variation, and human-unique residues — all accessible through an intuitive analytics interface.

Teams trust CodeXome to bring biological clarity to complex data

Built on empirical evidence

Deep-time biology uncovers structure and function that population datasets alone cannot reveal — improving confidence in variant classification.

Resolves uncertainty

Surfaces human-unique alleles

Prioritizes functional domains

Designed for real-world genomics workflows

Whether you’re in R&D, clinical variant review, or academic research, CodeXome fits naturally into existing pipelines and annotation systems.

Works with ClinVar + UniProt

Complements gnomAD & REVEL

Supports research and clinical teams

Immediate value, minimal setup

A browser-based experience means no compute setup, pipelines, or installation. Simply upload or explore, and insights appear instantly.

No installation

No coding required

Fast onboarding

Here’s how it works

It’s as simple as explore → evaluate → interpret

CodeXome reveals deep-time evidence in three clear steps.

Step 1

Explore the Gene

Search any gene to instantly view evolutionary constraint, primate recurrence, domains, motifs, and annotated functional regions.

Step 2

Evaluate Variants

Upload a VCF or input individual variants to view recurrence, absence, human-unique classification, and integrated functional annotations.

Step 3

Interpret With Confidence

Combine evolutionary tolerance with existing population and predictive datasets to rapidly classify VUS and understand functional context.

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Evolution creates the missing evidence population data can’t show

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Evolution fills the functional gap
Deep-time recurrence shows which amino-acid substitutions biology tolerated across 55 primate lineages, revealing functional limits that never appear in human-only cohorts.

Deep-time evidence scales with your workload
‍Whether you are reviewing a single VUS or thousands of exome calls, CodeXome applies the same evolutionary constraints across your entire gene list in seconds.

Multiple hands of diverse individuals placed on a tree trunk in a forest.

Hereditary cancer gene set

See how Deep Time Ancestry reshapes interpretation for BRCA1/2, ATM, and related genes by aligning evolutionary evidence with curated pathogenicity.

Read the Study