CodeXome Knowledge Center

What "orthogonal evidence" actually means, why it's not just another conservation score, and how a second, independent measurement changes what's possible in variant interpretation.

A BRCA1 case study in how CodeXome resolves a real variant of uncertain significance using primate evolutionary evidence, not a predicted score.

Human-only comparisons capture only recent variation and miss the deep evolutionary constraints that actually define gene function.

Human-derived data alone leaves most variation unresolved; evolutionary time is the missing axis of biological evidence.

Nature spent 87 million years testing which gene changes are survivable. CodeXome reads that record to help researchers interpret human variants.

Oncology is entering a new era‚ one where personalized treatment isn't just a vision but a rapidly maturing reality. At the center of this shift is CodeXome.

Every gene has its own evolutionary tempo and pressure points, and those patterns are essential to understanding which variants drive disease.

Why the VUS problem persists despite more sequencing, and how evolutionary genomics introduces a biologically grounded new source of evidence.

Why manual filtering remains a major bottleneck in variant interpretation, and how evolutionary evidence opens a scalable path forward.

As testing scales to exomes and genomes, allele frequency alone cannot resolve the significance of most rare variants.

Population databases describe what exists in human cohorts, but only evolution can tell you what biology tolerated across 80 million years.

The 18-month clinical integration roadmap, team, and validation milestones funded by the Phase II award.

Quickly look up any gene of interest and view its description, aliases, cross-references, and comparative genomics data.

We had an incredible time at ASHG 2025 and left energized by the level of interest in new approaches to variant interpretation.