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Platform guides, scientific concepts, and research workflows for evolutionary constraint evidence.

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Try: VUS constraint VCF DTAS pipeline
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Documentation
6 guides
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Scientific Concepts
6 articles
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Workflow Guides
4 walkthroughs
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Comparisons
4 analyses
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News and Insights
4 posts
New to CodeXome?
Start here
1
Understand the science
Read Evolutionary Constraint Explained to learn the biology behind the platform.
2
See it in action
Follow From VCF to Candidate Variant for a complete analysis walkthrough.
3
Integrate with your tools
Learn how to export and use results in R, Python, or your existing pipeline.
Popular articles
1
What Are Variants of Uncertain Significance?
Scientific Concepts
2
From VCF to Candidate Variant
Workflow Guide
3
Evolutionary Evidence vs ML Predictors
Comparisons
4
Understanding the Gene Profile
Documentation
5
Evolutionary Constraint Explained
Scientific Concepts
6
Understanding DTAS Scores
Documentation
All
Documentation
Concepts
Workflows
Comparisons
News
24 articles
Uploading a VCF
Accepted formats, file size limits, and starting an annotation run.
Docs
4 min
Understanding the Gene Profile
Reading constraint patterns, phylogenetic alignments, and integrated database context.
Docs
6 min
Exporting and Using Results
TSV format, column definitions, and integrating into R, Python, or Excel.
Docs
5 min
Understanding DTAS Scores
What DTAS measures, how to interpret ranges, and using scores for prioritization.
Docs
5 min
What Is Variant Prioritization?
Narrowing hundreds of candidates to a shortlist for functional follow-up.
Concepts
8 min
Evolutionary Constraint Explained
What constraint across primate evolution means and why it matters.
Concepts
10 min
Human-Unique vs Shared Variants
The biological difference between primate-shared and human-only variants.
Concepts
7 min
Observation vs Prediction in Genomics
Direct evolutionary observation compared to ML-based pathogenicity prediction.
Concepts
9 min
From VCF to Candidate Variant
The complete CodeXome analysis workflow in one guide.
Workflows
8 min
Integrating CodeXome into Your Pipeline
How TSV exports fit alongside gnomAD, ClinVar, REVEL, and other tools.
Workflows
7 min
Evolutionary Evidence vs Population Frequency
Why allele frequency and evolutionary constraint answer different questions.
Comparisons
8 min
Evolutionary Evidence vs ML Predictors
Direct observation from primate evolution compared to prediction-based scores.
Comparisons
10 min
NSF SBIR Phase II: $1.225M Funding
The 18-month clinical integration roadmap funded by Phase II.
News
4 min

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